Key result
The authors hypothesize that genetic variation in UCP1 gene expression among different ethnic groups could contribute to the ethnic-specific predisposition to cardio-metabolic diseases.
The authors hypothesize that genetic variation in UCP1 gene expression among different ethnic groups could contribute to ethnic-specific predispositions to cardio-metabolic diseases.
May explain ethnic cardio-metabolic disparities; hypothesis-generating and requires prospective validation.
Cardio-metabolic diseases (CMDs) comprise a cluster of risk factors that contribute to chronic pathological conditions with adverse consequences for cardiovascular function and metabolic processes. A wide range of CMD prevalence rates among different ethnic groups has been documented. In view of accumulated evidence, there is a trend toward increasing CMD prevalence rates in Eastern Europe and Western Asia. Numerous studies have revealed an association between uncoupling protein 1 (UCP1) gene variants and CMDs. UCP1 activity is essential for brown adipose tissue (BAT)-mediated thermogenesis. Experimental animal studies and epidemiological studies in humans highlight the significance of BAT-mediated thermogenesis in protecting against obesity and maintaining a lean phenotype. We hypothesize that the genetic variation in UCP1 gene expression observed among different ethnic groups could contribute to the ethnic-specific predisposition to CMD development. Constructing such prevalence maps of UCP1 gene variants could contribute significantly into identifying high-risk ethnic groups predisposed to the development of CMDs, and further shaping public health policies by the improvement of existing preventive and management strategies.
No takes yet. Share an insight, caveat, or question.
Flouris et al. (2017) studied Cardio-metabolic diseases. UCP1 gene variants was evaluated. The authors hypothesize that genetic variation in UCP1 gene expression among different ethnic groups could contribute to the ethnic-specific predisposition to cardio-metabolic diseases.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: