Key result
AKAP79 interacts with KCNQ2-5, but not KCNQ1-containing channels, and this interaction is disrupted by calcified calmodulin but not by PIP2 depletion.
Population
Chinese hamster ovary (CHO) cells heterologously expressing KCNQ1-5 subunits and AKAP79
Comparison
Co-expression of AKAP79, wild-type or… vs Cells expressing KCNQ channels without AKAP79…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open relevance to human channel regulation or disease.
AKAP79 specifically interacts with KCNQ2-5 channels to sensitize them to muscarinic inhibition, a process disrupted by calcified calmodulin but independent of PIP2 depletion.
Bal et al. (2010) studied this question. AKAP79/150 and Ca2+/Calmodulin was evaluated on FRET efficiency between CFP-tagged KCNQ channels and YFP-tagged AKAP79. AKAP79 interacts with KCNQ2-5, but not KCNQ1-containing channels, and this interaction is disrupted by calcified calmodulin but not by PIP2 depletion.
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