Key result
Polymorphisms in the ATP1B1, RGS5, and SELE genes were associated with hypertension and systolic blood pressure in African-Americans, with effect sizes of approximately 2-3 mmHg.
Why the study?
Do polymorphisms in the ATP1B1, RGS5, and SELE genes associate with hypertension and blood pressure in African-Americans?
Population
968 African-Americans
Design
Case-control
Authors
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May inform ancestry-specific genetic research; should not yet influence hypertension management.
Case-Control (n=968)
Do polymorphisms in the ATP1B1, RGS5, and SELE genes associate with hypertension and blood pressure in African-Americans?
Effect estimate: 2-3 mmHg
p-value: p=9.3 × 10
Polymorphisms in the ATP1B1, RGS5, and SELE genes are associated with hypertension and systolic blood pressure regulation in African-Americans.
Faruque et al. (2011) conducted a case-control in hypertension (n=968). Polymorphisms in ATP1B1, RGS5 and SELE genes was evaluated on hypertension and systolic blood pressure (2-3 mmHg, p=9.3 × 10). Polymorphisms in the ATP1B1, RGS5, and SELE genes were associated with hypertension and systolic blood pressure in African-Americans, with effect sizes of approximately 2-3 mmHg.
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