Key result
HSV-1-based vectors offer specific advantages and disadvantages for stable, targeted gene delivery into postmitotic neurons compared with other viral vectors.
This overview describes the biology, advantages, and disadvantages of HSV-1-based vectors for gene delivery into neurons compared to other vectors.
HSV-1 vectors merit consideration for targeted neuronal gene delivery; leaves open head-to-head clinical comparisons to guide selection.
This overview describes the considerations involved in the preparation and use of a herpes simplex virus type 1 (HSV-1) amplicon as a vector for gene transfer into neurons. Strategies for gene delivery into neurons, either to study the molecular biology of brain function or for gene therapy, must utilize vectors that persist stably in postmitotic cells and that can be targeted both spatially and temporally in the nervous system in vivo. This unit describes the biology of HSV-1 along with a discussion covering development of amplicon and genomic HSV-1 vectors. Advantages and disadvantages of current HSV-1 vectors are presented, and HSV-1 vectors are compared with other vectors for gene transfer into neurons.
No takes yet. Share an insight, caveat, or question.
Rachael L. Neve (2012) conducted a review in Gene transfer into neurons. HSV-1-based vectors vs. Other vectors was evaluated. HSV-1-based vectors offer specific advantages and disadvantages for stable, targeted gene delivery into postmitotic neurons compared with other viral vectors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: