September 15, 1978Biochemical JournalOpen Access

Prostaglandin receptors on human platelets. Structure-activity relationships of stimulatory prostaglandins

View Full Paper

Ask AI

Bookmark

Population

Human platelets

Design

Preclinical

Authors

DMD. Euan MacIntyreCenter for Advancing Health ESE W SalzmanBoston University JGJohn L. GordonQatar Petroleum (Qatar)

Discussion

Member takes

Implication

May guide prostaglandin analogue design for platelet studies; leaves open in vivo relevance and clinical translation.

Structured PICO

Population

Human platelets

Intervention

Synthetic analogues of prostaglandins E2 or F2a, prostaglandin endoperoxides (G2 and H2), synthetic analogues of prostaglandin H2, and arachidonic acid

Outcome

Platelet aggregation and release of 5-hydroxytryptamine from platelet dense bodiessurrogate

The study identifies critical structural determinants for prostaglandin-induced platelet aggregation, highlighting the role of specific receptor interactions.

Cite This Study

MacIntyre et al. (1978) studied this question.

synapsesocial.com/papers/6a9039532a22b8e8a92da43a https://doi.org/10.1042/bj1740921

View Full Paper

Ask AI

Bookmark

Prostaglandin receptors on human platelets. Structure-activity relationships of stimulatory prostaglandins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Prostaglandin receptors on human platelets. Structure-activity relationships of stimulatory prostaglandins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider