June 1, 1977European Journal of BiochemistryOpen Access

On the Interrelationship of Prostaglandin Endoperoxide G2 and Cyclic Nucleotides in Platelet Function

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Population

Human platelets (in vitro)

Design

Preclinical

Authors

HCHans‐Erik ClaessonMount Sinai Hospital CMCurt MalmstenKarolinska Institutet

Discussion

Member takes

Implication

ADP mediates PGG2 platelet effects; extends mechanistic models but leaves open human antithrombotic translation.

Structured PICO

Population

Human platelets (in vitro)

Intervention

Prostaglandin endoperoxide G2

Outcome

Platelet aggregation, release of ADP and [14C]serotonin, and cyclic nucleotide (cAMP/cGMP) levelssurrogate

The study provides mechanistic evidence that prostaglandin G2-induced platelet aggregation and modulation of cAMP levels are primarily mediated by the rapid release of ADP.

Cite This Study

Claesson et al. (1977) studied this question.

synapsesocial.com/papers/6a90824cfdaee66aea8411e0 https://doi.org/10.1111/j.1432-1033.1977.tb11593.x

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Bookmark

On the Interrelationship of Prostaglandin Endoperoxide G2 and Cyclic Nucleotides in Platelet Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

On the Interrelationship of Prostaglandin Endoperoxide G2 and Cyclic Nucleotides in Platelet Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider