Key result
Direct fetal intravenous administration of amiodarone for drug-resistant fetal tachycardia resulted in transient fetal hypothyroidism in two reported cases.
Why the study?
Does direct fetal intravenous administration of amiodarone cause fetal hypothyroidism in fetuses with drug-resistant tachycardia?
Does direct fetal intravenous administration of amiodarone cause fetal hypothyroidism in fetuses with drug-resistant tachycardia?
Direct fetal intravenous administration of amiodarone for drug-resistant fetal tachycardia can cause transient fetal hypothyroidism.
Monitor fetal thyroid function after direct amiodarone; case reports leave open incidence and causality in resistant tachycardia.
Amiodarone, an anti-arrhythmic drug that contains 39% iodine, is rarely known to cause negative effects on fetal thyroid function after gestational exposure, when given orally to a pregnant woman. Two cases of fetal hypothyroidism after gestational exposure to amiodarone by direct fetal intravenous route are described here.
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Vanbesien et al. (2001) studied this question. Direct fetal intravenous administration of amiodarone for drug-resistant fetal tachycardia resulted in transient fetal hypothyroidism in two reported cases.
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