Key result
SR proteins are required for the interaction of the U1 small nuclear ribonucleoprotein complex with the 5' splice site of pre-mRNA, and individual SR proteins promote interaction at distinct alternative splice junctions.
This basic science study demonstrates that SR proteins direct alternative 5' splice site selection by regulating the assembly of U1 snRNP onto the pre-mRNA.
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Hypothesis-generating for spliceosome-targeted therapies; leaves open clinical translation in human cardiovascular disease.
Zahler et al. (1995) studied this question. SR proteins vs. Control (no SR proteins) was evaluated on U1 snRNP interaction with 5' splice site. SR proteins are required for the interaction of the U1 small nuclear ribonucleoprotein complex with the 5' splice site of pre-mRNA, and individual SR proteins promote interaction at distinct alternative splice junctions.
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