January 1, 1985Postgraduate Medical JournalOpen Access

Use of amiodarone during pregnancy

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Population

2 pregnant women with arrhythmias

Design

Case_series

Follow-up

Up to 2 months post-partum

Authors

DRD. RobsonSt Vincent's Hospital Sydney MRMarun RajSaveetha University GSG. StoreyThe University of Sydney

Discussion

Member takes

Implication

May support cautious amiodarone use in refractory cases; leaves open need for larger prospective studies before practice change.

Structured PICO

Population

2 pregnant women with arrhythmias (one 31-year-old with atrial fibrillation and mitral stenosis, one 27-year-old primigravida with paroxysmal atrial tachycardia)

Intervention

Amiodarone (Case 1: 200 mg/d throughout the entire pregnancy; Case 2: up to 200 mg three times daily for the final 17 weeks of pregnancy)

Outcome

Fetal outcome and placental transfer of amiodarone and its desethyl metabolitesafety

Amiodarone use during pregnancy resulted in normal fetal outcomes in two cases despite limited placental transfer, though caution remains advised due to limited data.

Limitations

Limited data available

Cite This Study

Robson et al. (1985) studied this question.

synapsesocial.com/papers/6a903c0cc63bb9fb07dd8007 https://doi.org/10.1136/pgmj.61.711.75

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Use of amiodarone during pregnancy

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Use of amiodarone during pregnancy

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider