Key result
Defective interfering particles play a pivotal role in biotechnology by stimulating the immune system and attenuating live viruses, but they can also interfere with vaccine production and facilitate viral persistence.
This review highlights the dual role of defective interfering particles in virology, acting both as potential immunostimulatory adjuvants and as factors that can hinder vaccine production and promote viral persistence.
Defective interfering particles (DIPs) are products of inner deletion mutants of viruses that reproduce at the disbursement of the parent virus. This review article aimed at reviewing current science on DIPs of their molecular and immunological features, role in disease progression and persistence, impact on vaccine production and viral vectors, and future directions. Defective interfering particles are very important to the field of biotechnology and genetic engineering due to their nature of stimulating the immune system and attenuating some of the live viruses during live-attenuated vaccine production, however, they have a devastating effect like interfering with vaccine production, that is decreasing the viral titer, and facilitate pathogenesis and persistence of some viral infections.
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Alemayehu Reta (2017) conducted a review in Viral infections. Defective Interfering Particles (DIPs) was evaluated. Defective interfering particles play a pivotal role in biotechnology by stimulating the immune system and attenuating live viruses, but they can also interfere with vaccine production and facilitate viral persistence.
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