Why the study?
What are the pharmacokinetic parameters of a single dose of rimantadine in healthy young adults and children?
What are the pharmacokinetic parameters of a single dose of rimantadine in healthy young adults and children?
A single dose of rimantadine is well tolerated and has a similar half-life in young adults and children, suggesting once-daily dosing may be suitable.
Answers are grounded in this paper and cite their sources.
Supports once-daily rimantadine dosing across ages; extends adult PK data to children.
Single doses of rimantadine were given to children and young adults to evaluate the safety and pharmacokinetics of this antiviral compound. The half-life of rimantadine in young adults was 27.7 +/- 4.9 h for tablets and 27.8 +/- 8.0 h for syrup preparations. A total of 10 children, 5 to 8 years old, received a syrup preparation of rimantadine. The half-life of rimantadine in children was 24.8 +/- 9.4 h. A single dose of rimantadine was well tolerated in young adults and children.
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Anderson et al. (1987) studied this question.
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