Why the study?
Does rimantadine prophylaxis in children prevent influenza A infection in children and reduce transmission within families?
Population
145 volunteers from 35 families during a naturally occurring outbreak of influenza A (H1N1) infection
Comparison
Rimantadine hydrochloride prophylaxis in children vs Placebo
Design
RCT, Randomized, Double-blind, placebo-controlled
Authors
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Supports rimantadine prophylaxis in children to prevent influenza A; confirms efficacy and extends to reduced family transmission.
Does rimantadine prophylaxis in children prevent influenza A infection in children and reduce transmission within families?
Rimantadine prophylaxis in children is highly effective at preventing influenza A infection in children and may reduce transmission to adult family members.
Richard D. Clover (1986) studied this question.
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