Why the study?
Does rimantadine improve protection against influenza A virus-induced cytopathic effects compared to amantadine in ferret tracheal ciliated epithelium?
Population
Ferret tracheal ciliated epithelium organ cultures infected with influenza A/Alaska/6/77 or A/Bangkok/1/79…
Comparison
Rimantadine hydrochloride added before or after… vs Amantadine hydrochloride and drug-free infected…
Design
Preclinical, single-blind
Follow-up
up to 21 days
Authors
Loading...
May suggest rimantadine superiority in ferret epithelium; hypothesis-generating and leaves open translation to human influenza therapy.
Does rimantadine improve protection against influenza A virus-induced cytopathic effects compared to amantadine in ferret tracheal ciliated epithelium?
Rimantadine provides greater protection against influenza A-induced cytopathic effects than amantadine at clinically relevant concentrations in a ferret tracheal organ culture model.
Burlington et al. (1982) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: