Why the study?
Does low-dose rimantadine prevent influenza A virus infection and illness in healthy adults?
Population
228 healthy adult volunteers recruited from Baltimore and Columbus. Excluded if history of seizures…
Comparison
Rimantadine hydrochloride 100 mg oral daily for… vs Identical-appearing placebo capsule daily for 6…
Design
RCT, Assigned randomly, according to a computer-generated code, Double-blind…
Follow-up
6 weeks
Authors
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Supports low-dose rimantadine for influenza A prophylaxis in healthy adults; confirms efficacy in this RCT.
Does low-dose rimantadine prevent influenza A virus infection and illness in healthy adults?
Low-dose (100 mg daily) rimantadine is well tolerated and highly effective for the prevention of influenza A illness in healthy adults.
Brady et al. (1990) studied this question.
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