Key result
Essential hypertension in women was associated with a significant decrease in bone mineral density compared with normotensive subjects, and BMD was inversely correlated with systolic blood pressure.
Why the study?
Is essential hypertension associated with reduced bone mineral density in women?
Cross-Sectional
Is essential hypertension associated with reduced bone mineral density in women?
Essential hypertension in women is associated with significantly reduced bone mineral density and increased urinary calcium excretion.
Supports hypertension-BMD association in women; hypothesis-generating and requires prospective studies before clinical consideration.
Recent studies have reported the abnormalities in calcium metabolism at the systemic level in human hypertension as well as in experimental hypertension. Because bone is the largest store of calcium in the body, the bone calcium content and mineralization may represent the entire calcium balance. The present study was undertaken to investigate the bone mineral density (BMD) in women with essential hypertension by means of the dual-energy X-ray absorptiometric (DXA) method. The DXA analysis showed a significant decrease in BMD in female hypertensive subjects compared with normotensive subjects. In addition, the BMD was inversely correlated with systolic blood pressure in women. The 24-h urinary calcium excretion was significantly greater in female hypertensive subjects than in female normotensive subjects. Furthermore, the greater the urinary calcium excretion, the lower the BMD in women. The values of serum total calcium, total magnesium, ionized calcium, and 1, 25(OH)2 vitamin D were not different between hypertensive and normotensive subjects. The results of the present study demonstrated that DXA provided an index of whole calcium balance, and suggest that high blood pressure might be associated with reduced BMD in female hypertension.
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Kazushi Tsuda (2001) conducted a cross-sectional in Essential hypertension. Essential hypertension vs. Normotension was evaluated on Bone mineral density (BMD). Essential hypertension in women was associated with a significant decrease in bone mineral density compared with normotensive subjects, and BMD was inversely correlated with systolic blood pressure.
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