Key result
Increasing Tropomodulin in the nucleus severely hampered myogenic differentiation and selectively suppressed muscle-specific gene expression in myogenic cells.
Tropomodulin traffics through the nucleus and its increased nuclear presence hampers myogenic differentiation, suggesting a novel nuclear role for this cytoskeletal protein.
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Nuclear Tropomodulin may regulate myogenesis; leaves open its role in human muscle disorders pending in vivo validation.
Kong et al. (2004) studied Myogenic differentiation. Increasing Tropomodulin (Tmod) in the nucleus vs. Wild-type Tmod was evaluated on Myogenic differentiation and muscle-specific gene expression. Increasing Tropomodulin in the nucleus severely hampered myogenic differentiation and selectively suppressed muscle-specific gene expression in myogenic cells.
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