July 1, 1991Circulation Research

Mechanism of sustained mechanical alternans. Effect of variations in ventricular billing volume.

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Population

18 dogs

Design

Preclinical

Authors

DADavid AdlerUniversity of Rochester Medical Center SNSrdjan NikolićUniversity of Belgrade ESE H SonnenblickUniversity of Parma

Discussion

Member takes

Implication

Supports contractile-state mechanism of SMA in animals; hypothesis-generating for human arrhythmia risk without practice change.

Structured PICO

Population

18 dogs (8 dogs for direct slope determination, 10 dogs for measuring mitral and aortic flow in 55 series of sustained mechanical alternans)

Intervention

Experimental manipulation of filling volume using a remote-controlled mitral valve and mathematical modeling of stroke volume-end-diastolic volume relations

Outcome

Slope of the stroke volume-end-diastolic volume (SV-EDV) curve (gamma)surrogate

Sustained mechanical alternans is primarily driven by an alternating contractile state rather than the Frank-Starling mechanism.

Cite This Study

Adler et al. (1991) studied this question.

synapsesocial.com/papers/6a90401dccd91641af4dce87 https://doi.org/10.1161/01.res.69.1.26

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Mechanism of sustained mechanical alternans. Effect of variations in ventricular billing volume.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism of sustained mechanical alternans. Effect of variations in ventricular billing volume.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider