Why the study?
Does indomethacin pretreatment alter cerebral blood flow and arachidonic acid metabolite levels in Mongolian gerbils after transient cerebral ischemia?
Population
Mongolian gerbils anesthetized with pentobarbital subjected to 10 or 20 minutes of dense forebrain ischemia
Comparison
Pretreatment with indomethacin vs No pretreatment and a separate non-ischemic…
Design
Preclinical
Follow-up
up to 100 minutes of reperfusion
Authors
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Indomethacin may shift eicosanoid balance after cerebral ischemia in gerbils; hypothesis-generating in animals, no clinical translation yet.
Does indomethacin pretreatment alter cerebral blood flow and arachidonic acid metabolite levels in Mongolian gerbils after transient cerebral ischemia?
Cyclooxygenase inhibition with indomethacin reduces cyclooxygenase metabolites but increases lipoxygenase metabolites (LTB4) after transient cerebral ischemia, suggesting a shift in arachidonic acid metabolism.
Dempsey et al. (1986) studied this question.
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