Key result
Arachidonic acid induces endothelium-dependent relaxation of bovine coronary arteries, which is mediated by both cyclooxygenase products (PGI2) and cytochrome P-450 metabolites (EETs).
Population
Bovine coronary arteries contracted with U-46619
Design
Preclinical
Authors
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Hypothesis-generating in bovine arteries; leaves open whether dual PGI2/EET pathways translate to human coronary tone.
Arachidonic acid induces relaxation of bovine coronary arteries through both cyclooxygenase-derived PGI2 and cytochrome P-450-derived EETs.
Rosolowsky et al. (1993) studied Vascular tone regulation. Arachidonic acid and various inhibitors (indomethacin, BW755C, SKF 525a) was evaluated on Relaxation of bovine coronary arteries. Arachidonic acid induces endothelium-dependent relaxation of bovine coronary arteries, which is mediated by both cyclooxygenase products (PGI2) and cytochrome P-450 metabolites (EETs).
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