Population
Normal and hypercholesterolemic rabbit aortas and cultured rabbit aortic endothelial cells
Comparison
Arachidonic acid and its partially purified… vs Normal rabbits or baseline…
Design
Preclinical
Authors
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Indicates endothelial lipoxygenase activity in hypercholesterolemia; leaves open metabolite identification and human relevance.
The endothelium produces an unknown lipoxygenase metabolite of arachidonic acid that causes vasorelaxation and may regulate vascular tone in both normal and hypercholesterolemic states.
Pfister et al. (1996) studied this question.
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