Key result
Recent premorbid blood pressure control was strongly related to acute lacunar events at younger ages (<65 years) (P=0.0002), but not in patients ≥65 years.
Observational
p-value: p=0.0002
Poor recent premorbid blood pressure control is strongly associated with acute lacunar events in younger patients (<65 years), emphasizing the critical need for rapid and effective hypertension management in this demographic.
Age-specific premorbid BP differences by stroke subtype are hypothesis-generating; leaves open questions on mechanisms and clinical relevance.
OBJECTIVE: To determine the age-specific temporal trends in blood pressure (BP) before acute lacunar vs nonlacunar TIA and stroke. METHODS: In a population-based study of TIA/ischemic stroke (Oxford Vascular Study), we studied 15-year premorbid BP readings from primary care records in patients with lacunar vs nonlacunar events (Trial of Org 10172 in Acute Stroke Treatment [TOAST]) stratified by age (<65, ≥65 years). RESULTS: = 0.0002). However, no similar differences in BP were observed in patients ≥65 years of age. CONCLUSION: Recent premorbid BP control is strongly temporarily related to acute lacunar events at younger ages, suggesting a direct role of BP in accelerating causal pathology and highlighting the need to control hypertension quickly.
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Li et al. (2018) conducted an observational in TIA and ischemic stroke. Premorbid blood pressure was evaluated on Temporal trends in blood pressure before acute lacunar vs nonlacunar events (p=0.0002). Recent premorbid blood pressure control was strongly related to acute lacunar events at younger ages (<65 years) (P=0.0002), but not in patients ≥65 years.
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