Key result
Patients with atrial fibrillation prescribed aspirin had a significantly higher rate of stroke (38.5%) compared to those prescribed warfarin (12.8%).
Why the study?
The study was conducted to highlight the importance of adequate anticoagulant therapy and its correlation with a higher risk of stroke in patients with atrial fibrillation.
Does adequate anticoagulant therapy reduce the risk of stroke in patients with atrial fibrillation compared to antiplatelet or no therapy?
Population
103 patients with atrial fibrillation, including 39 who had a stroke
Comparison
Stratification by CHADS2, CHA2DS2-VASc, and HASBLED scores and prescribed antithrombotic therapies
Design
Observational study
Authors
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May signal age bias in AF anticoagulation; hypothesis-generating and should not yet change practice.
Observational (n=103)
No
Does adequate anticoagulant therapy reduce the risk of stroke in patients with atrial fibrillation compared to antiplatelet or no therapy?
Absolute Event Rate: 38.5% vs 12.8%
p-value: p=0.0001
There is a significant gap between guideline-recommended anticoagulant prescribing and actual clinical practice for AF patients, with underuse of anticoagulants correlating with higher stroke rates.
Mašić et al. (2019) conducted an observational in Atrial fibrillation (n=103). Aspirin vs. Warfarin was evaluated on Stroke occurrence (p=0.0001). Patients with atrial fibrillation prescribed aspirin had a significantly higher rate of stroke (38.5%) compared to those prescribed warfarin (12.8%).
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