Diastereoselective alkylation reaction of the chiral 6-ethoxypiperidinones (4) and (5) has been developed and successfully applied to the asymmetric synthesis of piperidine alkaloids, (+)- and (-)-coniines (11) and (12), (-)-sedamine (21), and (-)-allosedamine (22)
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Naito et al. (1990) studied this question.
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