Key result
Central angiotensin II significantly elevated p-tau levels and induced cognitive impairment in normal rat brains, which was attenuated by losartan and a GSK 3β inhibitor.
Why the study?
Does central angiotensin II induce Alzheimer-like tau phosphorylation and cognitive impairment in normal rat brains?
Population
Normal rat brains
Comparison
Central angiotensin II vs Control (implied); Losartan and a GSK 3β inhibitor
Design
Preclinical
Authors
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Central angiotensin II may promote tau pathology in rats; leaves open whether ARBs affect Alzheimer's in humans.
Does central angiotensin II induce Alzheimer-like tau phosphorylation and cognitive impairment in normal rat brains?
Angiotensin II may be a crucial mediator of Alzheimer's disease pathology, providing a mechanistic link between cardiovascular events and Alzheimer's disease.
Tian et al. (2012) studied Alzheimer-like tau phosphorylation. Central angiotensin II vs. Losartan and GSK 3β inhibitor was evaluated on p-tau levels and cognitive impairment. Central angiotensin II significantly elevated p-tau levels and induced cognitive impairment in normal rat brains, which was attenuated by losartan and a GSK 3β inhibitor.
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