Why the study?
Does half-strength ACD solution reduce hypocalcemia and QT prolongation compared to standard ACD during plateletpheresis?
Population
Donors undergoing plateletpheresis with intermittent flow centrifuge (n=27 procedures)
Comparison
Half-strength ACD solution during plateletpheresis vs Standard ACD solution during plateletpheresis
Design
Cohort
Follow-up
Immediate postpheresis
Authors
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May mitigate hypocalcemia and QT prolongation in plateletpheresis; leaves open whether RCTs should change practice.
Does half-strength ACD solution reduce hypocalcemia and QT prolongation compared to standard ACD during plateletpheresis?
Half-strength ACD solution during plateletpheresis mitigates citrate-induced hypocalcemia and QT prolongation compared to standard ACD.
Cox et al. (1977) studied this question.
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