Key result
Bibliometric analysis of 2,013 articles from 2015-2024 revealed a steady increase in publications on macrophages in hypertension, with inflammation and oxidative stress as major research hotspots.
Why the study?
As research on macrophages and hypertension increases substantially, identifying critical research areas and unraveling potential interaction mechanisms has become essential.
Systematic Review (n=2,013)
This bibliometric analysis highlights the growing global research interest in the role of macrophages and inflammation in hypertension over the past decade.
Growing macrophage-hypertension research highlights inflammation as a hotspot; leaves open whether macrophage targeting will yield clinical therapies.
Background: Hypertension continues to be a global health and economic burden, conventionally characterized by a chronic inflammatory state. Macrophages are critical for the initiation, progression and manifestation of hypertension. As studies on the relationship between macrophages and hypertension increase substantially, identifying critical research areas and unraveling potential interaction mechanisms become increasingly essential. Methods: Articles associated with hypertension and macrophages in recent 10 years were retrieved from the Web of Science Core Collection for analysis, using Microsoft Excel, VOSviewer, CiteSpace and Scimago Graphica. Results: After excluding studies that did not meet inclusive standard based on time (2015-2024) and type (article or reviews), 2,013 original articles related to macrophages associated with hypertension were included. The number of publications has been increasing annually. These records consisted of 2,013 English language papers published in 351 journals by 315 institutions or regions from 83 countries/regions between 2015 and 2024. We analyzed the co-cited references clusters to objectively outline the current state of research, including the regulatory mechanisms of hypertension, diseases related to hypertension, and the lifestyle factor. Inflammation remains one of the most popular research hot-spot. The most popular publishing journal in this field is PLOS ONE and the most prolific writer is Li, Hui-Hua. The primary keywords cluster in this field is inflammation, with the highest occurrences and TLS among the top 10 keywords. Conclusion: These comprehensive and visualized bibliometric results summarized the significant findings in macrophage-related hypertension studies over the past 10 years. Macrophages appear to be effective in the treatment of hypertension as potential targets, but further research is needed to clarify the specific pathophysiological mechanisms involved.
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Wang et al. (2025) conducted a systematic review in Hypertension (n=2,013). Macrophage research in hypertension was evaluated on Publication trends, hotspots, and citation networks. Bibliometric analysis of 2,013 articles from 2015-2024 revealed a steady increase in publications on macrophages in hypertension, with inflammation and oxidative stress as major research hotspots.
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