Why the study?
Does aortic valve incompetence alter hemodynamics and systemic perfusion in a mock circulation model of continuous flow VAD support?
Population
Mock circulation loop simulating continuous flow ventricular assist device support with varying levels of…
Comparison
Simulated aortic valve incompetence across a… vs Simulated normal aortic valve function (implied)
Design
Preclinical
Authors
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May compromise perfusion in C-VAD patients with aortic valve incompetence; leaves open optimal speed strategies in humans.
Does aortic valve incompetence alter hemodynamics and systemic perfusion in a mock circulation model of continuous flow VAD support?
Aortic valve incompetence in the setting of continuous flow VAD support leads to wasteful recirculation, decreased systemic perfusion, and increased risk of hemolysis and thrombosis due to higher shear stress.
Garcia et al. (2008) studied this question.
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