Population
Glutaraldehyde-fixed target epithelial cells and live trypomastigotes of Trypanosoma cruzi
Comparison
Fab fragment derived from monoclonal antibodies… vs Untreated cells or parasites; confluent versus…
Design
Preclinical
Authors
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Hypothesis-generating for T. cruzi invasion mechanisms; does not support clinical translation of 160-kDa inhibition.
T. cruzi invasion involves polarized, receptor-mediated attachment that can be inhibited by targeting a specific 160-kDa parasite surface molecule.
Schenkman et al. (1991) studied this question.
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