Key result
T. cruzi trypomastigote membrane fragments and killed parasites inhibit living trypomastigote attachment to heart myoblasts.
Population
Rat heart myoblasts
Comparison
Membrane fragments from trypomastigote forms of… vs Membrane fragments from non-invasive epimastigotes
Design
Preclinical
Authors
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Supports trypomastigote-specific receptor on cardiac cells in vitro; leaves open molecular identity and in vivo relevance.
The study provides in vitro evidence for the existence of a specific host cell surface receptor on rat heart myoblasts that mediates Trypanosoma cruzi infection.
Kierszenbaum et al. (1985) studied Trypanosoma cruzi infection. Membrane fragments from trypomastigote forms of Trypanosoma cruzi vs. Membrane fragments from non-invasive epimastigotes was evaluated on Association of intact trypomastigotes with rat heart myoblasts. Membrane fragments from trypomastigote forms of Trypanosoma cruzi and killed trypomastigotes inhibited the association of intact living trypomastigotes with rat heart myoblasts.
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