Preparation of hemolysate‐filled hexamethylene sebacamide microcapsules with controlled diameter

Hemolysate‐filled hexamethylene sebacamide microcapsules (nylon‐6, 10 membranes) were prepared by interfacial polymerization. Sheet lattice, frame lattice, turbine and marine impellers were tested to control the microcapsule mean diameter and size distribution parameters. Mean diameters ranging from 40 to 200 μm were obtained depending on the impeller type, rotational speed and emulsifier concentration. The size dispersion of microcapsule preparations was best controlled with a frame lattice impeller, achieving standard deviation values less than 40% of the mean diameter. The wire diameter and mesh dimensions of the impeller lattice had little effect on the distribution parameters.