Key result
Phylogenetic and Bayesian inference of HoBi-like pestivirus genomes confirms three main clades and suggests emergence in Asia with subsequent spread to Brazil between 1890 and 1962.
Why the study?
Complete genome sequencing data for HoBi-like pestivirus is scarce.
Phylogenetic analysis suggests HoBi-like pestivirus emerged in Asia and was introduced to Brazil between 1890 and 1962, likely via importation of water buffalo and indicine cattle.
Adds five new Brazilian HoBiPeV genomes; extends global evolutionary data but leaves open links to clinical disease severity.
The HoBi-like pestivirus (HoBiPeV), currently classified as Pestivirus H species, is a pathogen associated with a broad spectrum of clinical manifestations in ruminants, particularly in cattle. Since HoBiPeV complete genome sequencing data is scarce, in the present study we described five nearly complete new Brazilian HoBiPeV genomes and further perform a more complete genetic and evolutionary characterization with all additional genome sequences available in the GenBank database. Entropy and selection pressure analysis showed the E2 gene, a surface glycoprotein, is the most variable gene, which also displays the greatest number of sites under positive selection. Phylogenetic and Bayesian inference based on complete genome and Npro gene, respectively, from all HoBiPeV sequences available so far, confirms the existence of three main clades (a, b, and c). The abovementioned analysis suggests that this pestivirus species probably emerged in Asia and spread to different regions including Brazil, where only strains belonging to specific genetic group ‘a’ have been found. The hypothesis of the HoBiPeV introduction in Brazil (between 1,890 and 1,962), formulated based on Bayesian inference, coincides with a period of intensive importation of water buffalo (Bubalus arnee) and indicine cattle (Bos taurus indicus) from Asia to Brazil, suggesting that this could be the origin of the current Brazilian HoBiPeV genetic group ‘a’.
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Silveira et al. (2020) studied HoBi-like pestivirus (HoBiPeV) infection. Phylogenetic and evolutionary analysis of HoBi-like pestivirus genomes was evaluated on Genetic and evolutionary characterization. Phylogenetic and Bayesian inference of HoBi-like pestivirus genomes confirms three main clades and suggests emergence in Asia with subsequent spread to Brazil between 1890 and 1962.
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