July 1, 1981The Journal of Biochemistry
Phosphorylation of Microtubule-Associated Proteins (MAPs) and pH of the Medium Control Interaction between MAPs and Actin Filaments1
Population
Microtubule-associated proteins (MAPs) and actin filaments (in vitro model)
Comparison
Phosphorylation of MAPs and changes in pH vs Unphosphorylated MAPs and neutral pH
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating for pH-dependent cytoskeletal regulation; leaves open relevance to mammalian physiology or disease.
Structured PICO
P
Population
Microtubule-associated proteins (MAPs) and actin filaments (in vitro model)
I
Intervention
Phosphorylation of MAPs and changes in pH
C
Comparator
Unphosphorylated MAPs and neutral pH
O
Outcome
Interaction and crosslinking ability between MAPs and actin filaments (measured by low-shear viscosity)surrogate
The interaction between MAPs and actin filaments can be dynamically regulated by MAP phosphorylation and small changes within the physiological pH range.
Cite This Study
Nishida et al. (1981) studied this question.