January 1, 2009Mediators of InflammationOpen Access

Adipokines in Nonalcoholic Steatohepatitis: From Pathogenesis to Implications in Diagnosis and Therapy

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Population

Patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, as well as experimental…

Design

Review

Authors

Discussion

Should not yet change NAFLD management; leaves open adipokines as diagnostic markers and targets pending prospective validation.

Population

Patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), as well as experimental models

Intervention

Evaluation of adipokines (leptin, adiponectin, resistin, tumor necrosis factor-a, and interleukin-6)

Outcome

Role in pathogenesis, progression, noninvasive diagnosis, and potential therapeutic targets in NASH

Adipokines play a significant role in the pathogenesis of NASH and may serve as noninvasive diagnostic markers and future therapeutic targets.

Tsochatzis et al. (2009) studied this question.

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