Cytokines and the pathogenesis of non-alcoholic steatohepatitis
Key result
Obesity and insulin resistance are major risk factors for primary non-alcoholic steatohepatitis, potentially mediated by immunomodulatory cytokines produced by adipose tissue.
Design
Review
Authors
Discussion
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Implication
Supports metabolic risk stratification in NASH; leaves open cytokine-specific targets for trials.
PICO
P
Population
Non-alcoholic steatohepatitis (NASH)
This review discusses the role of cytokines, obesity, and insulin resistance in the pathogenesis of non-alcoholic steatohepatitis (NASH).
Cite This Study
Diehl et al. (2005) conducted a review in Non-alcoholic steatohepatitis (NASH). Obesity and insulin resistance are major risk factors for primary non-alcoholic steatohepatitis, potentially mediated by immunomodulatory cytokines produced by adipose tissue.