Key result
This review discusses the etiology and pathogenesis of nonalcoholic steatohepatitis, emphasizing the critical roles of obesity, insulin resistance, and molecular mechanisms of hepatotoxicity.
This review highlights the roles of obesity and insulin resistance in the pathogenesis of nonalcoholic steatohepatitis to aid in developing therapeutic targets.
May inform NASH therapeutic targeting of obesity and insulin resistance; leaves open prospective validation of molecular mechanisms.
Incidence of nonalcoholic fatty liver disease is increasing with an estimated prevalence of 20-30% in developed nations. This is leading to increased incidence of chronic liver disease, cirrhosis, and hepatocellular cancer. It is critical to understand the etiology and pathogenesis of any disease to create therapeutic targets and develop new treatments. In this paper we discuss the etiology and pathogenesis of nonalcoholic steatohepatitis with special focus on obesity, role of insulin resistance, and molecular mechanisms of hepatotoxicity.
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Guturu et al. (2012) conducted a review in Nonalcoholic steatohepatitis. Obesity and insulin resistance was evaluated. This review discusses the etiology and pathogenesis of nonalcoholic steatohepatitis, emphasizing the critical roles of obesity, insulin resistance, and molecular mechanisms of hepatotoxicity.
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