Key result
NASH drives cirrhosis and liver cancer linked to metabolic syndrome via inflammation and fibrosis.
Key points are not available for this paper at this time.
Design
Review
Alerts clinicians to screen for NASH in metabolic syndrome; leaves open targeted antifibrotic therapies.
Nonalcoholic steatohepatitis is a major cause of cirrhosis and liver cancer. It is associated with visceral adiposity and the metabolic syndrome and is nearly as common as type 2 diabetes. Metabolic stress, inflammation, and fibrosis are the primary pathogenic mechanisms.
No takes yet. Share an insight, caveat, or question.
Diehl et al. (2017) studied this question. Nonalcoholic steatohepatitis is a major cause of cirrhosis and liver cancer associated with visceral adiposity and metabolic syndrome, driven by metabolic stress, inflammation, and fibrosis.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: