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Nonalcoholic steatohepatitis is a major cause of cirrhosis and liver cancer associated with visceral adiposity and metabolic syndrome, driven by metabolic stress, inflammation, and fibrosis.
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This review discusses the cause, pathogenesis, and treatment of nonalcoholic steatohepatitis, highlighting its association with metabolic syndrome.
Nonalcoholic steatohepatitis is a major cause of cirrhosis and liver cancer. It is associated with visceral adiposity and the metabolic syndrome and is nearly as common as type 2 diabetes. Metabolic stress, inflammation, and fibrosis are the primary pathogenic mechanisms.
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Diehl et al. (2017) studied this question. Nonalcoholic steatohepatitis is a major cause of cirrhosis and liver cancer associated with visceral adiposity and metabolic syndrome, driven by metabolic stress, inflammation, and fibrosis.
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