Good to high conversions (70–100 %) into optically active tri- or tetracyclic nitrogen-containing compounds 1 based on 1,2-dihydroisoquinolines and 1,2-dihydrophthalazines proceed with high diastereoselectivity (d.r.≥15:1) and good to excellent enantioselectivity (85–96 % ee) in the presence of a chiral amine.
No takes yet. Share an insight, caveat, or question.
Frisch et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: