The Most Promising Targeted Preparation for the Treatment of Migraine from the Pathophysiological Mechanism: Aimed at CGRP Drugs

Migraine is a common disorder of brain dysfunction. At present, there are four theories: trigeminal neurovascular theory, vascular dysfunction theory, neurogenic inflammation theory, and diffusion inhibition theory, which provide new ideas for the treatment of migraine. In recent years, the study of CGRP (calcitonin gene-related peptide) receptor antagonists and CGRP-targeted antibodies has made breakthroughs in the treatment of migraine. By blocking or inhibiting the effects of CGRP, these drugs can effectively reduce the attack frequency and pain degree of migraine, with good efficacy and safety. New migraine prophylactic drugs, such as CGRP receptor monoclonal antibodies and small molecule CGRP receptor antagonists have been developed and approved, and some anti-CGRP drugs have shown good efficacy and safety in clinical trials, making anti-CGRP drugs a new and effective clinical treatment for migraine, providing more options and hope for the treatment of migraine. This paper explores the mechanism of action, efficacy and safety of anti-CGRP drugs. With the continuous development of science and technology, it is believed that more drugs will appear in the future, bringing more treatment options for migraine patients.