Mutation analysis of TRPC6 gene in nephrotic syndrome in children from a single center

We analyzed the correlation between two single nucleotide polymorphism sites (rs12366144 and rs7931399) on TRPC6 gene and primary nephrotic syndrome (PNS). 205 cases of Guangxi Zhuang children were selected, of which 108 cases were in the PNS group and 97 cases were in the healthy control group who came to our hospital for physical examination in the same period. The rs12366144 and rs7931399 loci of the TRPC6 gene were genotyped using second-generation genetic testing technology, and their correlation with the development of PNS was analyzed. Logistic regression analysis was used for association analysis. Haplogroup construction was also performed for both loci using SHEsis software to analyze the association between both loci and PNS. The polymorphisms at rs12366144, rs7931399 loci of TRPC6 gene may not be significantly related to the development of primary nephrotic syndrome in Guangxi Zhuang children.