What question did this study set out to answer?

To evaluate the efficacy and drug concentrations of intraluminal antibiotic therapy for central venous catheter-related bloodstream infections in patients receiving home parenteral nutrition.

November 1, 1995Clinical Infectious Diseases

Intraluminal Antibiotic Treatment of Central Venous Catheter Infections in Patients Receiving Parenteral Nutrition at Home

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To evaluate the efficacy and drug concentrations of intraluminal antibiotic therapy for central venous catheter-related bloodstream infections in patients receiving home parenteral nutrition.
Conducted an open, uncontrolled, prospective study in patients with subcutaneously tunneled central venous catheter bloodstream infections receiving parenteral nutrition at home.
Treated 7 bacterial infections with intraluminal antibiotics (mean duration, 8.6 days) alongside short systemic antibiotic courses (mean duration, 2.1 days), and 2 fungal infections with intraluminal amphotericin B.
Monitored intraluminal concentrations of vancomycin and gentamicin during catheter lock periods and analyzed fungal isolates using pulsed-field DNA electrophoresis.
All 7 bacterial infections (100%) were successfully cured using intraluminal antibiotic treatment.
Both Candida infections (100%, 2 of 2) were suppressed during intraluminal amphotericin B therapy but later relapsed, as confirmed by pulsed-field DNA electrophoresis typing.
Intraluminal concentrations of vancomycin and gentamicin started at approximately 5 mg/mL and remained at or above 2.5 mg/mL throughout catheter lock duration.

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Implication

Prospective uncontrolled study demonstrates high cure rates for bacterial catheter infections in home parenteral nutrition patients, highlighting intraluminal antibiotic lock feasibility.

Cite This Study

Benoit et al. (1995) studied this question.

synapsesocial.com/papers/6a906309e02ba012352db57e https://doi.org/10.1093/clinids/21.5.1286

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Implication

Prospective uncontrolled study demonstrates high cure rates for bacterial catheter infections in home parenteral nutrition patients, highlighting intraluminal antibiotic lock feasibility.

Intraluminal Antibiotic Treatment of Central Venous Catheter Infections in Patients Receiving Parenteral Nutrition at Home

Key Points

Discussion

Implication

Cite This Study

Intraluminal Antibiotic Treatment of Central Venous Catheter Infections in Patients Receiving Parenteral Nutrition at Home

Key Points

Discussion

Implication

Cite This Study

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