Why the study?
Does propranolol alter platelet function and fibrinolytic activity compared to metoprolol in hypertensive and migraine patients?
Does propranolol alter platelet function and fibrinolytic activity compared to metoprolol in hypertensive and migraine patients?
Nonselective beta-blockade with propranolol increases platelet aggregability and alters fibrinolytic activity compared to beta-1 selective blockade with metoprolol.
May support preferring metoprolol to limit platelet effects; leaves open impact on clinical events in hypertension or migraine.
Summary: Two groups of hypertensives and a group of migraine sufferers were tested during treatment with the nonselective β-blocker propranolol and the β1-selective metoprolol. During treatment with propranolol, an increased platelet aggregability and a decrease in platelet content of cyclic AMP were seen when compared with metoprolol treatment. In addition, propranolol treatment increased the plasma level of adrenaline as well as the euglobulin clot lysis time.
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K. Winther (1987) studied this question.
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