Key result
Propranolol administered at therapeutic doses did not significantly affect measurable platelet function in healthy young subjects.
Why the study?
Does oral propranolol affect platelet function in healthy young subjects?
Does oral propranolol affect platelet function in healthy young subjects?
Therapeutic doses of oral propranolol do not significantly affect measurable platelet function in healthy subjects.
Therapeutic propranolol unlikely to alter platelet function in healthy young adults; leaves open effects in cardiovascular patients or with antiplatelet therapy.
Propranolol, a non-selective beta blocker, was administered orally in therapeutic doses. The effects of a single dose (160 mg) and one week's treatment (80 mg twice a day) on platelet function were compared in healthy young subjects. There were no significant changes in circulating platelet aggregates, template bleeding time, platelet factor 3 availability and thromboxane beta 2 (TX beta 2) generation. Platelet aggregation responses as assessed by angle of slope and maximal percentage aggregation (all agonists) and lag phase (collagen) showed no changes of biological importance, although minor changes reaching significance were observed with some agonists. These findings suggest that propranolol does not significantly affect platelet function when taken at doses commonly encountered in clinical practice.
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Barradas et al. (1990) studied Healthy. Propranolol was evaluated on Platelet function (circulating platelet aggregates, template bleeding time, platelet factor 3 availability, and thromboxane beta 2 generation). Propranolol administered at therapeutic doses did not significantly affect measurable platelet function in healthy young subjects.
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