Why the study?
Ventricular outflow tract PVC is commonly mediated by triggered activity, which carvedilol may suppress by inhibiting store overload-induced Ca2+ release.
Does carvedilol reduce the burden of premature ventricular complexes originating from the ventricular outflow tract in patients with structurally normal hearts?
Does carvedilol reduce the burden of premature ventricular complexes originating from the ventricular outflow tract in patients with structurally normal hearts?
In a small retrospective cohort, carvedilol significantly reduced the 24-hour burden of outflow tract premature ventricular complexes in patients with structurally normal hearts.
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Carvedilol may suppress OT-PVCs; hypothesis-generating in cohort data and leaves open need for RCTs before practice change.
Hwang et al. (2020) studied this question.
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