What question did this study set out to answer?

To document the emergence, genetic reversion, and geographic distribution of vaccine-derived polioviruses in the Democratic Republic of the Congo during 2017 and assess the initial outbreak response.

March 15, 2018MMWR Morbidity and Mortality Weekly ReportOpen Access

Vaccine-Derived Poliovirus Outbreaks and Events — Three Provinces, Democratic Republic of the Congo, 2017

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Population

25 vaccine-derived poliovirus cases reported in three provinces in the Democratic Republic of the Congo…

Design

Other

Authors

MAMary AllemanCenters for Disease Control and Prevention RCRohit ChitaleLos Alamos National Laboratory CBCara C. BurnsCenters for Disease Control and Prevention

Discussion

Member takes

Implication

Requires sustained VDPV surveillance in DRC; leaves open optimal OPV strategies for eradication.

Key Points

To document the emergence, genetic reversion, and geographic distribution of vaccine-derived polioviruses in the Democratic Republic of the Congo during 2017 and assess the initial outbreak response.
Epidemiological and laboratory surveillance across three provinces (Tanganyika, Maniema, and Haut Lomami) through March 8, 2018.
Evaluation of supplementary immunization activities (SIAs) conducted from June through December 2017 to curb transmission.
A total of 25 vaccine-derived poliovirus cases were confirmed in 2017, including 20 cVDPV2 cases originating in Haut Lomami, two cVDPV2 cases in Maniema, and isolated cases in Tanganyika.
Circulation of cVDPV2 likely continued into 2018 due to limitations in acute flaccid paralysis surveillance and suboptimal geographic scope and quality of response SIAs.

Structured PICO

Population

25 vaccine-derived poliovirus (VDPV) cases reported in three provinces in the Democratic Republic of the Congo during 2017 (as of March 8, 2018)

Intervention

Outbreak response supplementary immunization activities (SIAs) conducted during June-December 2017

Outcome

Reported cases of vaccine-derived polioviruses (VDPVs)

Ongoing circulation of vaccine-derived poliovirus in the DRC highlights the need for improved surveillance and supplementary immunization activities.

Limitations

limitations in surveillance
suboptimal SIA quality and geographic scope

Cite This Study

Alleman et al. (2018) studied this question.

synapsesocial.com/papers/6a906f45779e50c2dc90b9af https://doi.org/10.15585/mmwr.mm6710a4

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Vaccine-Derived Poliovirus Outbreaks and Events — Three Provinces, Democratic Republic of the Congo, 2017

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Vaccine-Derived Poliovirus Outbreaks and Events — Three Provinces, Democratic Republic of the Congo, 2017

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

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