September 24, 2015BMC Infectious DiseasesOpen Access

Managing the risk of circulating vaccine-derived poliovirus during the endgame: oral poliovirus vaccine needs

View Full Paper

Ask AI

Bookmark

Population

Global population modeled as 710 subpopulations of roughly equal size averaging approximately 10 million…

Comparison

Intensive supplemental immunization activities… vs Scenarios without tOPV intensification prior to…

Design

Other

Authors

RTRadboud J. Duintjer TebbensMassachusetts Department of Public Health KTKimberly M. ThompsonKidney Research UK

Discussion

Member takes

Implication

May inform intensified pre-OPV2 cessation SIAs; leaves open real-world feasibility and validation.

Structured PICO

Population

Global population modeled as 710 subpopulations of roughly equal size averaging approximately 10 million people (as of 2013), grouped into 71 blocks stratified by World Bank income level and polio vaccine use.

Intervention

Intensive supplemental immunization activities (SIAs) with homotypic OPV (trivalent OPV and bivalent OPV) shortly before planned coordinated cessation.

Comparator

Scenarios without tOPV intensification prior to OPV2 cessation.

Outcome

Expected paralytic cases from serotype 2 and serotype 1 polioviruses and estimated OPV doses required.

Mathematical modeling indicates that preventing circulating vaccine-derived poliovirus outbreaks during OPV cessation requires a substantial short-term increase in targeted OPV supplemental immunization activities.

Limitations

Uncertainty about the true population size and wastage
Simplified characterization of national RI schedules
Global model does not characterize actual individual countries

Cite This Study

Tebbens et al. (2015) studied this question.

synapsesocial.com/papers/6a907227a9a6d70ff18a53bf https://doi.org/10.1186/s12879-015-1114-6

View Full Paper

Ask AI

Bookmark

Managing the risk of circulating vaccine-derived poliovirus during the endgame: oral poliovirus vaccine needs

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Managing the risk of circulating vaccine-derived poliovirus during the endgame: oral poliovirus vaccine needs

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider