What question did this study set out to answer?

To review published transmission and risk models and evaluate immunization options and potential consequences of coordinating global cessation of bivalent oral poliovirus vaccine (bOPV) in 2027.

June 21, 2023Risk AnalysisOpen Access

Coordinated global cessation of oral poliovirus vaccine use: Options and potential consequences

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Why the study?

Eradicating poliomyelitis requires ending all OPV use globally, but plans for bivalent OPV cessation remain undefined despite strategic plan recommendations highlighting the need for early planning.

Key Points

To review published transmission and risk models and evaluate immunization options and potential consequences of coordinating global cessation of bivalent oral poliovirus vaccine (bOPV) in 2027.
Applied integrated global risk, economic, and poliovirus transmission modeling frameworks aligned with Global Polio Eradication Initiative (GPEI) strategic plans.
Evaluated bOPV cessation scenarios planned for 2027, under the operational assumption that OPV use will not be restarted for routine immunization after cessation.
Identified no feasible options for bOPV cessation likely to succeed without actively intensifying bOPV coverage to elevate population immunity prior to withdrawal.
Observed ongoing challenges from persistent type 2 poliovirus transmission and outbreak-response OPV use, underscoring the operational complexity introduced by novel vaccines like nOPV2.

Structured PICO

Population

Global population (implied by global cessation modeling)

Intervention

Coordinated global cessation of bivalent oral poliovirus vaccine (bOPV) in 2027

Outcome

Potential consequences of globally coordinating bOPV cessation

Successful global cessation of bivalent oral poliovirus vaccine will likely require a strategy of bOPV intensification to increase population immunity prior to cessation.

Discussion

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Implication

Undefined bOPV cessation plans sustain OPV risks; leaves open the path to full polio eradication.

Cite This Study

Kalkowska et al. (2023) studied this question.

synapsesocial.com/papers/6a70d6898031ec7bb1dc9d2d https://doi.org/10.1111/risa.14158

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Coordinated global cessation of oral poliovirus vaccine use: Options and potential consequences

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Coordinated global cessation of oral poliovirus vaccine use: Options and potential consequences

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

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