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September 16, 2020Risk AnalysisOpen Access

Globally coordinating cessation of OPV3 as soon as possible offers the opportunity to reduce cases of vaccine-associated paralytic polio globally and reduce the risks of creating serotype 3 circulating vaccine-derived polioviruses.

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Why the study?

Following certification of serotype 3 wild poliovirus eradication while serotype 1 continues to transmit, the optimal timing of serotype 3 oral poliovirus vaccine cessation remained an open question.

Does globally coordinated cessation of serotype 3 oral poliovirus vaccine (OPV3) before serotype 1 OPV reduce cases of vaccine-associated paralytic polio and circulating vaccine-derived polioviruses globally?

Comparison

Different options for coordinated cessation of OPV3 prior to COVID-19

Design

Integrated global modeling study

Authors

DKDominika A. KalkowskaKTKimberly M. Thompson

Discussion

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Member takes

Overview

Persistent serotype 1 transmission renders prior OPV cessation timelines obsolete; leaves open updated polio endgame strategies.

Structured PICO

Does globally coordinated cessation of serotype 3 oral poliovirus vaccine (OPV3) before serotype 1 OPV reduce cases of vaccine-associated paralytic polio and circulating vaccine-derived polioviruses globally?

P
Population
Global population (modeled)
I
Intervention
Globally coordinated cessation of serotype 3 oral poliovirus vaccine (OPV3) before serotype 1 OPV
C
Comparator
Different options for coordinated cessation
O
Outcome
Risks, costs, and benefits of global polio policy and risk management options (cases of vaccine-associated paralytic polio and circulating vaccine-derived polioviruses)

Early coordinated cessation of OPV3 could reduce vaccine-associated paralytic polio and the risk of circulating vaccine-derived polioviruses.

Cite This Study

Kalkowska et al. (2020) studied this question.

synapsesocial.com/papers/6a7100af53da1ffdb507b237https://doi.org/10.1111/risa.13590
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