Adenovirus type 5 infection reverses the interferon-induced antiviral state in HeLa cells via a late gene product.
Suggests viral interference in co-infections; leaves open the role of adenovirus late genes in modulating interferon responses in vivo.
HeLa cells treated with human lymphoblastoid interferon do not synthesize poliovirus proteins. The antiviral state against poliovirus is reversed if cells are previously infected with adenovirus type 5. A late gene product seems to be involved in this reversion, since no effect is observed at early stages of infection or in the presence of aphidicolin.
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Feduchi et al. (1987) studied this question.
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