Population
Cell cultures infected with DNA viruses and RNA virus
Comparison
Interferon treatment (e.g., 1,000 units) vs Untreated cells or cells infected with different…
Design
Preclinical
Authors
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Differential interferon sensitivity of RNA versus DNA viruses in cell culture; leaves open distinct resistance mechanisms in vivo.
The study demonstrates that in the same cell line, RNA and DNA viruses can have different sensitivities to interferon, suggesting separate resistance factors may exist.
Youngner et al. (1972) studied this question.