June 1, 1997Journal of Medical Virology

Detection of Coxsackie B Virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus

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Why the study?

Is enteroviral infection associated with the onset of adult type I diabetes mellitus?

Population

51 adults, comprising 12 newly diagnosed IDDM patients with ketosis or ketoacidosis, 12 patients with…

Design

Case-control

Authors

LALaurent AndréolettiCentre Hospitalier Universitaire de Reims DHDidier HoberLAC+USC Medical Center CHChristine Hober-VandenbergheCentre Hospitalier Universitaire de Lille

Discussion

Member takes

Implication

EV detection at adult IDDM onset may support viral trigger; hypothesis-generating and should not yet change practice.

Structured PICO

Is enteroviral infection associated with the onset of adult type I diabetes mellitus?

Population

51 adults, comprising 12 newly diagnosed IDDM patients with ketosis or ketoacidosis, 12 patients with metabolic decompensation in the course of IDDM, 12 patients with decompensated non-IDDM, and 15 healthy adults without presumed EV infection or metabolic disease.

Outcome

Detection of enteroviral (EV) genome in peripheral blood using reverse transcription and seminested polymerase chain reaction (seminested RT-PCR)surrogate

Coxsackie B virus RNA sequences are detectable in peripheral blood at the onset of adult type I diabetes, supporting a potential viral etiology for the disease.

Cite This Study

Andréoletti et al. (1997) studied this question.

synapsesocial.com/papers/6a90742f3f736c3f82c7a4ae https://doi.org/10.1002/(sici)1096-9071(199706)52:2<121::aid-jmv1>3.0.co;2-5

View Full Paper

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June 1, 1997Journal of Medical Virology

Detection of Coxsackie B Virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus

View Full Paper

Ask AI

Bookmark

Why the study?

Is enteroviral infection associated with the onset of adult type I diabetes mellitus?

Population

51 adults, comprising 12 newly diagnosed IDDM patients with ketosis or ketoacidosis, 12 patients with…

Design

Case-control

Authors

LALaurent AndréolettiCentre Hospitalier Universitaire de Reims DHDidier HoberLAC+USC Medical Center CHChristine Hober-VandenbergheCentre Hospitalier Universitaire de Lille

Discussion

Member takes

Implication

EV detection at adult IDDM onset may support viral trigger; hypothesis-generating and should not yet change practice.

Structured PICO

Is enteroviral infection associated with the onset of adult type I diabetes mellitus?

Population

Outcome

Detection of enteroviral (EV) genome in peripheral blood using reverse transcription and seminested polymerase chain reaction (seminested RT-PCR)surrogate

Coxsackie B virus RNA sequences are detectable in peripheral blood at the onset of adult type I diabetes, supporting a potential viral etiology for the disease.

Cite This Study

Andréoletti et al. (1997) studied this question.

synapsesocial.com/papers/6a90742f3f736c3f82c7a4ae https://doi.org/10.1002/(sici)1096-9071(199706)52:2<121::aid-jmv1>3.0.co;2-5

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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